Protein Structure from Scientific Research

Cartoon_tube representation of Anc5. Sphere representation indicates 45 substitution residues (purple) and two catalytic glutamic acids and one serine that holds catalytic water (magenta). Resides around 4 Å from loop II are shown in sticks. Intramolecular interactions stabilizing loop II regions are shown in the enlargements. Resides in Anc4 and Anc5 state are shown in gray and purple sticks, respectively. Black dashed lines indicate hydrogen bonds. Residue numbers are based on Anc4. In the case that the number shifts due to loop insertions, residue numbers of Anc5 state are in parentheses. An asterisk indicates the number of Anc4 + Loop II. Loop regions I to VI are shown in red, green, light blue, purple, orange, and cyan, respectively.

DOI