Conceptual paradigm depicting the synergistic mechanisms between host plants and rhizosphere microorganisms that improve drought resistance in wheat. The drought-resistant wheat cultivar determines the direct response of plants to recruit genotype-specific microbial communities, such as M. alpina . M. alpina can feedback to plants and improve drought resistance by activating the CIPK-PP2C network to induce drought-responsive genes. However, M. alpina and E. nigrum together have a negative effect on the lateral roots and root hairs of wheat and lead to wheat becoming significantly more sensitive to drought stress