Precision and recall after stepwise application of drug selection criteria. Bars with no pattern represent a zc cut-off that Guney et al. 10 had previously found to offer good coverage of known drug-disease pairs. The dotted pattern represents precision at zc < -1.64 (corresponding to one-sided P < 0.05). The striped pattern represents precision among candidates with zc < -1.64 and dc < 1 (in other words, candidates passing network proximity-based selection). The crosshatch pattern represents candidates passing network proximity and pharmacological action selection. The application of selection criteria substantially increased the precision among central cell types.
