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The numbers of metabolites and genes were calculated between two adjacent stages during pear flesh development. DAM was calculated from metabolome data, while DEG was calculated from transcriptome data. Genes correlated with DAMs between adjacent stages was isolated from the gene-metabolite database and referred to as “correlated genes”. The intersection of DEGs and correlated genes is referred to as “Correlated DEGs.” Correlated DEGs that were modified by DNA methylation are denoted as “DMR-modified correlated DEG.” S1 to S11 indicate the different stages of pear flesh development.

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