UMAP visualization of WT and CC16-/- mouse lung nuclei ( n = 154,136) across two loading inputs by integrating six animals with three replicates from each group. Nuclei are colored by their predicted cell type. The abbreviation of cell labels was described in Fig. 4 except for aEC (arterial endothelial cells), Endo-like (endothelial-like cells), and PNEC (pulmonary neuroendocrine cells).