GUIDE-Seq analysis performed with CjCas9 WT and UltraCjCas9. GUIDE-seq read counts of each on- and off-target in HEK293T cells are shown on the right side (extended data in Additional file 2 : Table S7–S10). In c and e , data are reported as mean standard deviation of n 3 biologically independent samples. Individual values are represented as empty circles
