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Representative scheme of PDH regulation. Ca2+binding in the mitochondrial matrix activates pyruvate dehydrogenase phosphatase 1 (PDP1), the Ca2+-dependent isoform of the PDP enzyme that, in turn, dephosphorylates and activates PDH, leading to acetyl-coenzyme A (CoA) production. Dichloroacetate (DCA) inhibits PDK.
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