Structural comparison of the inward facing partially open 1 (hOCT1-apo1) (magenta), partially open 2 (hOCT1-apo3) (gray), and fully open (hOCT1-apo2) (green) conformations with a close-up view of the unwinding of TM11 at G465 at the fully open conformation. G465 is shown as sphere. The partially open 1 state and partially open 2 state have different TM4 and TM11 conformations.
