Protein Structure from Scientific Research

A sliced view of the hOCT1 in the outward open (hOCT1-M1), outward occluded (hOCT1-M2), inward occluded (hOCT1-M3), and inward open (hOCT1-apo1) conformations. Metformin binds to the central pocket of hOCT1 in different states. The surface of the hOCT1 is colored according to the electrostatic potential calculated by ChimeraX.

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