Summary of the predicted minimum duration of protection half-life criteria for SMC towards achieving a target reduction in clinical incidence and severe disease for varying levels of SMC round and cycle coverage, shown for a 5-month seasonal profile in a setting with 50% access to first-line treatment, where SMC was deployed in four monthly cycles to children aged 3-59 months. Results show the estimated minimum duration of protection half-life with a 95% prediction interval higher than the given target reduction in clinical incidence (vertical axis), compared with a no intervention counterfactual and measured across the 4-month intervention period. Duration of protection half-life is defined as the number of days until the parasite killing effect of a drug reaches 50% of its maximum effect. Minimum criteria were calculated across Emaxlevels. Emax=maximum parasite killing rate per day. SMC=seasonal malaria chemoprevention.
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