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Expression of HDAC5 in U2OS cells restricts CPXV-BR plaque size. U2OS.TetR.EYFP or U2OS.TetR.HDAC5-FLAG cells were mock-induced or induced with 100 ng/mL doxycycline (dox) for 18 h and then infected with 100 PFUs of CPXV-BR per well. After 2 h of infection, the inoculum was removed and replaced with 1.0% carboxymethyl cellulose (CMC) in DMEM (+ dox where indicated). Plaque sizes in the presence (+) or absence (−) of dox were quantified and compared. n ≥ 32/condition.

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