Key findings include Nr5a2’s involvement in ZGA27and its crucial role in activating stage-specific genes at the 4- to 8-cell stage.29This study highlights Nr5a2’s targeting of ICM-specific genes, such as Oct4, to establish the pluripotency network, thereby ensuring ICM formation in blastocysts. Nr5a2 also functions as an auxiliary transcription factor, essential for self-renewal and maintenance of pluripotency.24
