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Open access visualization of Illustration, Model, RNA, Chromatin Fragments, PRC2
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Model. Left: in the presence of RNA (green), sonicated chromatin fragments are held in solution allowing for specific IP of PRC2-bound fragments. Middle: in samples treated with RNase A, non-specific fragments co-precipitate, reducing the relative enrichment of PRC2-bound genomic regions. This effect resembles the theoretical depletion of RNA-dependent PRC2 chromatin binding events. Right: the anionic polymer PGA (blue) maintains chromatin solubility in RNase A-treated samples, thereby restoring IP specificity and the detection of PRC2-bound genomic regions.

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