Signaling by different developmental patterning pathways (blue) is integrated in a cell-type-specific manner and a cell-type-specific set of transcription factors (blue) to drive the expression of a set of genes (blue) encoding for cell surface molecules (green), which are known to play a role in neuronal guidance and targeting. Thus, the combination of molecules displayed at the cell surface depends on the signal integration and fate specification at any position within the imaginal disc. Aberrant fate signals, for example, by the expression of oncogenic RasV12(orange), disrupt this cell-type-specific regulation of gene expression leading to a changed combination of cell surface molecules relative to that of the neighboring wild-type cell. The mismatch in cell surface molecules between neighboring cells induces all hallmarks of interface surveillance (red). Related to Figure S7.
