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Direct estimation of topographical coupling distance. Left, schematic illustration of the approach. Topographical coupling distance was computed as the mean of the pairwise distance matrix multiplied with the release relevance matrix to define weights. For details, seeSTAR Methods. Right, release relevance matrix for a synapse from the P21–23 age group and the CA model. Color scale indicates fractional contribution (red, high contribution; blue, low contribution).
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