Illustration from Scientific Research

Cys-loop superfamily NR subunits tagged in this study. For some NRs, two or three different tagged versions were made as indicated. Red asterisk, Lcch3, forms cationic channels with Grd and with CG8916 and chloride channels with Rdl.11,14,28The epitope tag was inserted into a poorly conserved region of the M3-M4 cytoplasmic loop in each NR subunit (Figures S1C and S1D). These proteins form homo- or heteropentameric channels.

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