Fold changes in ID50titers of the indicated cohorts against D614G, BA.5, and XBB.1.5 between pre- and post-vaccination or infection. Geometric mean fold changes in ID50titer are shown as black bars and denoted above the dots. Statistical analyses were performed by employing Wilcoxon matched-pairs signed-rank tests. Data for the BA.5 BV 2 cohort were extracted from a previously published study.