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Timeline representation of vaccine administration, SARS-CoV-2 infection, and serum collection intervals for each clinical cohort. Indicated time points represent the median in days for each cohort, with day 0 defined as the day of the initial SARS-CoV-2 vaccination. Numbers of participants for each group receiving a fourth wild-type (WT) monovalent vaccine (MV) is indicated. Other vaccine doses were received by all participants in each cohort. 15 participants from the Omicron infx + XBB.1.5 MV cohort had a pre-XBB Omicron infection (subgroup 1), while the other 10 had XBB infection (subgroup 2). N, sample size.

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