Protein Structure from Scientific Research

Summary of a 1-micros molecular dynamics (MD) simulation of RNF168R-UbcH5c bound to H2A-H2B, using the cryo-EM structure of RNF168R-UbcH5c-NCP as starting model. Here, 50 simulated RNF168R-UbcH5c models (gray) are overlaid relative to their E3 components. For comparison, RNF168R-UbcH5c conformations 1 (open state from a crystal structure) and 2 (closed state in the cryo-EM structure) are also included.

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