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Domain structure of medaka VE major subunits fZP1 and fZP3 in their soluble precursor (left), polymerized (center), and hatching enzyme-digested (right) forms. Vertical arrows indicate the specific recognition sites of the proteases regulating VE subunit polymerization and hatching. Note that, because fZP1 and fZP3 are secreted into the serum by the liver, their precursors lack a C-terminal transmembrane domain.

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