Amino acid alignments of heavy- (C) and kappa light-chain (D) variable domains of the unmutated ancestor IgM in patients P1 and P4 and the unmutated ancestor IgM for the anti-HCV E2 antibodies B04 and H04. IMGT numbering, with CDR flanking residues in bold. The V gene segment (dark gray), D gene segment (navy blue), J gene segment (green), and likely N-additions are shown in pink. Periods (.) indicate identity, and dashes (-) indicate gaps.
