CellChat analyses of cell–cell communication pathways between macrophages and proximal tubules epithelial cells isolated from Tet2 -/- and WT mouse kidneys. Data were analyzed using a two-tailed Student’s t -test or two-way ANOVA followed by Tukey’s or Bonferroni’s post hoc tests and are presented as the mean ± s.e.m. ** P < 0.01, *** P < 0.001; scale bar, 50 µm.