The origin of each variant is shown along with its detection across time points. Genes displayed on the left are ones that fall within the overlapping regions of interest of the two targeted NGS gene panels used (Methods). Alteration prevalence for each gene is listed on the right. The mutation count per sample is displayed at the top followed by rows indicating sample time point, pCR, CAP regression grading, OS, RFS and recurrence. Liquid biopsy analyses revealed 74 alterations in the 141 evaluable serial plasma samples obtained from the 32 patients. The variant repertoire consisted of 12 germline-derived variants, 27 CH-derived variants and 35 tumor-derived variants.
