UMAP from Scientific Research

Subclustering analysis of 997 EARLY-DEM + LATE-DEM donors, based on both attribute observations and their temporal manifestation. PP, primary progressive; RR, relapsingremitting; SP, secondary progressive. Left, wnn-UMAP scatterplot depicting the results of dimensionality reduction and clustering of clinical disease trajectories and CD accuracy (shape in which circle = accurate or unknown and triangle = inaccurate). Right, bar graph showing ND distribution with results of significance testing (one-sided Fisher’s exact test) for overrepresentation of: (1) ND across clusters (white asterisk) and (2) inaccurate diagnoses (black asterisk). FDR-corrected P values. + P <= 1 x 10 -1 , * P < 5.00 x 10 -2 , ** P < 5.00 x 10 -4 , *** P <= 5.00 x 10 -6.

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