'Dementia' temporal profiling ( n = 1,326 donors, of which n = 682 with 1 'dementia') showing density plot, KaplanMeier plot and three violin plots (center marker, box limits and whiskers represent the median, interquartile range (IQR) and 1.5 IQR). Two-sided MannWhitney U -test, FDR-corrected P values: * 1.00 10 -4 < P 1.00 10 -2 ; ** 1.00 10 -6 < P 1.00 10 -4 ; *** 1.00 10 -8 < P 1.00 10 -6 ; **** 1.00 10 -10 < P 1.00 10 -8 ; **** P 1.00 10 -10 .