Single-cell mRNA sequencing analysis of immunoglobulin receptor and global gene expression in CD19+CD20+B cells sorted from the blood of patient P1 at the clearance (HCV−) time point, with dimension reduction by uniform manifold approximation and projection (UMAP). Individual cells (denoted by dots) were annotated as the IGHV1-69 B cell clone (n= 849, red) or polyclonal cells based on their immunoglobulin sequence. Polyclonal naive (n= 490, brown) and memory B cells (n= 360, dark blue) were annotated according to landmark genes.
