Bubble Plot from Scientific Research

PredicTCR reactivity predictions for PDAC sample TIPC418 from Meng et al. 22 who tested eight TCRs and found none to react to the TIPC418-derived tumor cell line (blue dots, dot size scaled to number of TIL TCR clonotypes). PredicTCR analysis predicted seven of these eight TCRs to be nonreactive (reactivity scores below the Fisher–Jenk natural break threshold, dashed line in plot). Seven additional TCR clonotypes (red dots) predicted to be tumor reactive were cloned for prospective validation of predicTCR.

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