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Contour map and bar plots showing expression gradients of EMT- and hypoxia-related gene sets. Top: sample P3A_MBC; bottom: sample P4A_MBC. One-way ANOVA test was performed on box plots of inferred T reg proportions and expression of EMT- and hypoxia-related gene sets for regions in MBC. P values = 1.46 x 10 -29, 1.04 x 10 -36 and 0.12, respectively. Box plots indicate the median (center lines), interquantile range (hinges) and 1.5x interquartile range (whiskers). n = 5,366 and 1,888 spots in intratumoral regions, 5,608 and 7,104 spots in peritumoral regions, and 7,524 and 1,463 spots in stromal regions for TNBC and MBC, respectively. Intra, intratumoral; Peri, peritumoral.
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