Workflow from Scientific Research

Overview of the Starfysh workflow. From left to right: Starfysh input (ST dataset, signature gene lists for cell types or cell states and paired histology image (optional)), deconvolution (Starfysh defines anchor spots representative of cell types or states with the aid of archetypal analysis and infers cell type or state proportions and densities by accounting for ST technical artifacts), sample integration and downstream analysis (upon deconvolution, Starfysh jointly integrates multiple samples and characterizes spatial ‘hubs’ and further infers cell–cell interactions within each hub). NK, natural killer; PET, peripheral T.

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