Boxplot of the LFC at D34 in the Nutlin-treated condition for pegRNAs 20% editing with annotated residue functions. In all boxplots (g i), boxes indicate the median and interquartile range (IQR) for each sample with whiskers extending 1.5 IQR past the upper and lower quartiles. LFC calculated from the median values across n = 3 biologically independent samples using MAGeCK.