Line Plot from Scientific Research

Power simulation to detect significant effects on GATA1 expression as a function of enhancer effect sizes and sgRNA number. Power was computed by simulations of CRISPRi FlowFISH data, where sgRNA effects in the eHDAC6 element were scaled such that the average adjusted effect of all sgRNAs in the enhancer was 10–50% or unscaled ( n = 3 biological replicates).

DOI