The number of CREs that are significant in a CRISPR screen and overlap accessible chromatin regions, defined by ATAC-seq and DNase-seq and/or H3K27ac ChIPseq peaks (dark gray) or do not overlap those features in ten cell lines (A549: 4/4; GM12878: 14/14; HCT116: 3/3; HepG2: 2/2; Jurkat: 8/12; K562: 200/210; MCF-7: 3/3; NCI-H460: 1/1; PC-3: 1/1; WTC11: 65/66).
