Fumarate reduction in purified mitochondria from wild-type and SDHB knockout 143B cells with either DMSO, 10μM HKJS-001, or 100 nM HKJS-003. Data represent mean +/- SEM, n= 4 replicates fitted using a nonlinear regression. p value calculated using a parametric t test on the final time point. For all panels, *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001. See also Figures S5 and S6.
