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Schematic representation of CNGC15a and CNGC15c, including the calmodulin-binding domain (IQ), the six transmembrane helices S1–S6 and the N-terminal domain. The arrowheads indicate the position of the amino acid substitution P98S in CNGC15a GOF and the corresponding P104S substitution in CNGC15c GOF.

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