Line Plot from Scientific Research

Left: ELISA binding titers at day 56 for serum IgG binding to RBDs, represented as mean ED50values. Middle left: means of ELISA binding titers for each immunization. Middle right: means of ELISA binding titers for each immunization against only SARS-CoV-2 variant RBDs. Right: means of ELISA binding titers for each immunization against zoonotic sarbecovirus RBDs. Each circle represents the mean serum IgG binding titer against matched (solid circles) and mismatched (open circles) RBDs. The mean of mean titers is compared in (B) and (C) by Tukeys multiple comparison test with the Geisser-Greenhouse correction calculated using GraphPad Prism, with pairings by viral strain. Error bars associated with each data point are standard deviations. Significant differences between immunized groups linked by horizontal lines are indicated by asterisks:*p <0.05,**p <0.01,***p <0.001,****p <0.0001.

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