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The tRNA endoribonuclease SLFN11 links DNA damage responses with activation of RNA damage response pathways. ssDNA that accumulates because of DNA damage activates SLFN11, which then specifically cleaves tRNAs-UUA-Leu in the nucleus and the cytoplasm. The lack of corresponding tRNAs leads to the stalling of ribosomes at UUA codons, inducing ribosome collisions and subsequent activation of the ribotoxic stress response and integrated stress response.

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