Schematic of cell-autonomous parasite clearance. IRG and GBP proteins (magenta) are induced by STAT1 downstream of IFN signaling through the IFN- receptor (IFNGR). iNOS (purple) is transcriptionally co-regulated by STAT1 and NFkB downstream of Toll-like receptor (TLR) signaling and/or parasite effectors. IRG and GBPs are stored in vesicles and oligomerize on the parasitophorous vacuole (PV) and parasite plasma membranes contributing to T. gondii killing. iNOS is expressed in the cytosol and uses interaction partners to associate with membranes.
