Kinetics of anti-RBD antibodies in serum samples expressed as arbitrary units (arb. units). Red triangles: S-2P group ( n =21 on days 35, 14 and 3; n =20 post-challenge, n =1 clinical endpoints). Blue squares: S-V987H group ( n =21 on all timepoints). White circles: unvaccinated-challenged mice (Infected control) ( n =16 on days 35, 14 and 3; n =8 post-challenge, and n =8 clinical endpoints). Gray circles: uninfected and unvaccinated mice (Uninfected control) ( n =10). Groups in each time point were analyzed using two-sided Conover-Iman test with multiple comparison correction by FDR. Differences among animals within a particular group along time were analyzed using two-sided Friedman test with FDR correction.
