Percentage of weight variation in SARS-CoV-2 D614G-infected GSH over time. Statistical analysis was performed against the unvaccinated group using two-sided Kruskal-Wallis test correcting by FDR. Animals in S-2P, S-V987H and infected control were distributed as follows: days 0, 1, and 2 n = 12; days 3 and 4 n = 8; days 5, 6, and 7 n = 4. Uninfected control group n = 4 in each timepoint. Mean plus standard error of the mean (SEM) are shown * p < 0.05, ** p < 0.01, *** p < 0.001. Data represented in Fig. 4 correspond to one experiment. Source data are provided as a Source Data Fig. 4 .