Bar Plot from Scientific Research

Cell-type enrichment analysis. 20 categories of brain cell types are listed (from a total of 39 broad brain cell-type categories tested) along the vertical axis, and horizontal bar size represents the significance of the enrichment measured using MAGMA gene set enrichment test or partitioned LDSC. Color encodes results that were significant after false discovery rate correction. Bars in salmon color represent enrichments significant using both methods; green, MAGMA only; blue, partitioned LDSC only; and purple when neither method showed significant enrichment. 19 broad categories not displayed were not significant using either method. Columns represent the results of each test using summary statistics from MDD2013, MDD2018, and this study. The dotted line shows threshold of nominal (uncorrected) statistical significance.

DOI