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Figure shows the 3 meta-analyses conducted (middle, deeper blue). Predictive testing using polygenic risk scores was conducted using both European and all ancestries GWAS summary statistics (left-hand side of the figure). Bioinformatic and mechanistic analyses were conducted using European-only GWAS summary statistics because many of the methods depend on a single suitable linkage equilibrium reference panel, and methods to generalize these approaches to trans-ancestry summary statistics were still in development at the time of submission.

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