Illustration of a knockout’s impact on its partner stability, when the partner assembles co- or post-translationally. The coco subunits tend to be stabilized by their partner; hence, KO of the partner is expected to promote their misfolding and degradation. Such partner dependence is expected to be less marked among subunits assembling post-translationally, as they tend to be stable in the absence of their partner. Boxplots showing the distribution of protein abundance fold change (log2) upon partner knockout for predicted coco (orange) and post (cyan) subunits in yeast. Differences between the distributions are assessed by the MWU test.
