Heat map summarizing changes (normalized to steady state or saline-treated) to the indicated populations in long bones (exemplars of peak erythropoiesis, lymphopoiesis, granulopoiesis and myelopoiesis responses as shown in Supplementary Figs. 4 – 7 ) 2 days after phlebotomy (except for lymphopoiesis, which corresponds to day 8 as this is the time point with the lowest lymphopoiesis response, as shown in Supplementary Fig. 4 ), 6 days after L. monocytogenes infection, after 4 days of G-CSF treatment and at 20 months of age ( n = 7 (2 days after phlebotomy), 6 (6 days after phlebotomy), 4 (G-CSF) and 6 (20-month-old) mice).