Boxplot of change in binding free energy between DeepDirect- and random mutation-reconstructed NovavaxACE2 complex. n = 500 independent samples for each condition. a c , Boxplots show median, first and third quartiles and minimum and maximum. Outliers are classified as being 1.5-fold outside the interquartile range. D-N-ACE2-i, R-N-ACE2, D-N-ACE2-d represent mutations on Novavax-ACE2 complex via Deepdirect model inc , random process and Deepdirect model dec . D-ACE2, D-N-chain A, D-N-chain B and D-N-chain C represent specific mutations on ACE2, and chain A, B and C of Novavax, via Deepdirect model inc
