Tubulin cluster profile relative to class F compounds that have >85% similarity to the tubulin cluster profile. The selected profiles are those that have >85% similarity to the tubulin cluster profile and >20% induction at the lowest concentrations per compound. The reference profile is the first profile (100% biosimilarity) for which all subsequent profiles are compared. The tubulin profile has 424 features and is divided into three segments: cell, cytoplasm and nuclei. Biosim, biosimilarity to the tubulin cluster profile; ind, induction (percentage of significantly changed features relative to DMSO controls); and conc, concentration. The induction value reported is relative to the full CPA profiles with 579 features.
