Top: changes in TGA for each participant, computed from the sum of the body weight-adjusted SUV values per voxel, at day 14 versus baseline for those receiving GSK3036656 (ganfeborole) 30 mg (left) and GSK3036656 (ganfeborole) 1 mg (right). Bottom: changes in TAM, computed from the individual HU value per voxel + 1,000 to adjust for negative air values in the same participants. Data marked with an asterisk are from the participant illustrated in a . N by subject from left to right in the graph: N = 4,470, N = 4,824, N = 3,310, N = 4,916, N = 6,120, N = 755, N = 3,922, N = 1,459, N = 2,205, N = 2,826, N = 2,272, N = 1,626, N = 1,440, N = 2,531, N = 3,039, N = 7,701, N = 921, N = 944 and N = 3,971. Data are presented as mean values ( standard error of the mean).