Bootstrapped differences (n = 1,000 resamples with replacement stratifying by the output) between the statistics using plasma %p-tau217 (reference) and CSF biomarkers are shown in f for both the BioFINDER-2 cohort (left) and the Knight ADRC (right) cohort. The horizontal dashed line is plotted at zero, representing the lack of difference between plasma and CSF biomarkers. We considered plasma and CSF biomarkers clinically equivalent if the 95% CI of the mean difference included zero and clinically superior if it did not include zero and favored plasma (>0). Dots and error bars represent the actual statistic and 95% CI (from bootstrapped n = 1,000 samples with replacement), respectively. Vertical dashed lines represent the maximal AUC value possible (1).
