Schematic illustration of a balance between the five SGBs that were consistently higher in patients with PFS 12 months ( A. butyriciproducens SGB14993 group, I. bartlettii SGB6140, Dorea sp. AF24 7LB SGB4571, L. gasseri SGB7038 group and L. celerecrescens SGB4868) and the four SGBs that were found to be consistently higher in patients with PFS <12 months ( R. lactatiformans SGB15271, R. unclassified SGB15265 group, P. copri clade A SGB1626 and an unidentified SGB from the phylum Bacteroidetes SGB1957). In patients with PFS 12 and PFS <12 months, the balance is tilted to the left and right side, respectively.