For each microbial SGB listed, slopes are shown (that is, whether it is increasing or decreasing over study visits) in patients with PFS >=12 (n = 83) and PFS <12 months (n = 92), respectively. For increased readability, SGBs differentially abundant in only one study visit have been removed (see Extended Data Fig. 2 for all SGBs). Red and blue colors indicate whether the focal SGB is increasing or decreasing in its abundance over study visits, respectively, with the strength of the colors corresponding to the steepness of the slope, with darker shades indicating steeper increases/decreases. It then shows, in the teal-brown heatmap, the average difference between the two slopes (that is, between patients with PFS >=12 and PFS <12 months) across the different study visits. Non-gray cells in the heatmap correspond to the focal SGB's log fold change in abundance between patients with PFS >=12 and PFS <12 months, respectively. Teal cells correspond to study visits for which the abundance of the focal SGB is higher in patients with PFS >=12 than with PFS <12 months, and vice versa for brown cells (at 90% BCL). Gray cells denote differences between patients with PFS >=12 and PFS <12 months whose 90% credible interval cover zero.
