Validated ncDNVs and their impact on neighboring CHD-associated genes. Bar plots show RTqPCR analysis of genes adjacent to DNVs near ADAMTS6 in day 17 iPSC-CMs. Data are shown as mean s.d. of at least three independent experiments. ANOVA with Dunnetts test compared to wild-type (WT) control. REF and ALT sequences are shown to the right, with the SNV highlighted in yellow, along with predicted transcription factor binding motifs impacted by SNVs. All others, n = 4. **** P < 0.0001.
